Alpha-1 Antitrypsin Deficiency (A1-Antitrypsin Deficiency, A1AD) is a genetic disorder that causes defective production of Alpha-1 Antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.

Alpha-1 Canada’s mission is to provide information, education and support to Canadians affected by Alpha-1 Antitrypsin Deficiency; inform and educate the medical community about Alpha-1 Antitrypsin Deficiency; and generate broad awareness about this genetic liver, lung and skin disease.

Improving The Lives Of Alphas

donate funds

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Donating to Alpha-1 Canada provides patient support and funds our efforts to educate healthcare providers to advocate for Alpha-1 testing and to promote awareness for this rare genetic disease. To donate please visit  

donate blood

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Your contribution is important for a healthy and reliable blood supply and you will feel good knowing you have helped change a life. For a clinic near you please visit or 

donate plasma

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Plasma donation is critically important and contributes to saving lives. Your plasma will be used to create therapies that treat a variety of conditions and diseases, such as Alpha-1 Antitrypsin Deficiency. To locate a plasma donation clinic near you please visit or


donate life

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Sign your organ donor card and share your wishes with your family. One donor can save up to 8 lives through organ donation and enhance the lives of up to 75 more through the gift of tissue. Organ transplantation is another option for Alpha-1 patients with end-stage lung or liver disease. To find out how to register in your province please visit  

Thank-you to our generous funding partners!

DISCLAIMER:This website is designed to support, not replace, the relationship that exists between you and your physician. It is not the intention of this website to provide specific medical advice but rather to provide the Canadian Alpha-1 Community with information to better understand their health and their diagnosed disorder. Specific medical advice will not be provided and Alpha-1 Canada urges you to consult with a qualified physician for diagnosis and for answers to your personal questions.
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