• What is Alpha-1
    Antitrypsin Deficiency?

    Alpha-1 Antitrypsin Deficiency (A1-Antitrypsin Deficiency, A1AD) is a genetic disorder that causes defective production of Alpha-1 Antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.

Healthcare Provider Information
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Requisition forms

The diagnosis of Alpha-1 Antitrypsin Deficiency is based on a series of laboratory tests. Testing involves a routine serum test, and in cases where a low serum level is detected, additional confirmatory testing is required to identify and characterize the presence and severity of the genetic deficiency. Confirmatory testing is widely available to all Canadian physicians. Due to some of the regional differences of the requisition process, the information will be specific to each province. By clicking the button below, you will be redirected to the Grifols Canada website where requisition forms are available.

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Is their Asthma or COPD hereditary?

Your patient’s asthma or COPD could be a serious hereditary disease called Alpha-1 Antitrypsin Deficiency also called Alpha-1, A1AD or AATD which is a common serious hereditary disorder and can result in life-threatening lung, liver or skin disease. Knowing that your patient has Alpha-1 can greatly improve their quality of life. A positive diagnosis of Alpha-1 represents an opportunity to take concrete steps to avoid risk factors, limit symptoms, or slow the progression of symptoms they may already be experiencing. The Canadian Thoracic Society and Alpha-1 Canada recommend that everyone with COPD be tested for Alpha-1.

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DISCLAIMER: This website is designed to support, not replace, the relationship that exists between you and your physician. It is not the intention of this website to provide specific medical advice but rather to provide the Canadian Alpha-1 Community with information to better understand their health and their diagnosed disorder. Specific medical advice will not be provided and Alpha-1 Canada urges you to consult with a qualified physician for diagnosis and for answers to your personal questions.